This is a list of the current House seats and the incumbents occupying them. All 435 of these seats are up for election on 2 November 2010.

There have been 1 death, 7 resignations, and 1 change of party affiliation in the 111^th House.

• Congressman Rahm Emanuel (Democratic, Illinois CD 5) resigned 2 January 2009 (vacancy effective 3 January) to become President-elect Barack Obama's Chief of Staff.
• Congressman Kirsten Gillibrand (Democratic, New York CD 20) resigned 26 January 2009. Governor David Paterson (Democratic, New York) appointed Congresswoman Kirsten Gillibrand to fill the vacancy in the State's Class 1 seat caused by the resignation of now-Secretary of State Hillary Rodham Clinton.
• Congressman Hilda L. Solis (Democratic, California CD 32) resigned 24 February to become Secretary of Labor. The vacancy became effective 25 February 2009.
• Congressman H. Scott Murphy (Democratic, New York CD 20) was elected to Congress on 31 March 2009 in Special Election. He fills the vacancy caused by the appointment of Congressman Kirsten Gillibrand to the United States Senate. Congressman Murphy took the oath of office on 29 April 2009.
• Congressman Mike Quigley (Democratic, Illinois CD 5) was elected in a special election on 7 April 2009. He fills the seat formerly held by Congressman Rahm Emanuel who resigned to become President Obama's Chief of Staff.
• Congressman Ellen O. Tauscher (Democratic California CD 10) resigned on 26 June 2009 to become Undersecretary of State for Arms Control and International Security.
• Congressman Judy Chu (Democratic California CD 32) was elected in a special election on 14 July 2009. She will fill the vacancy caused by the resignation of Congressman Hilda L. Solis who became Secretary of Labor.
• Congressman John McHugh (Republican New York CD 23) resigned 21 September 2009 to become Secretary of the Army.
• Congressman John Raymond Garamendi (Democratic California CD 10) was elected in a special election 3 November 2009. He will fill the vacancy caused by the resignation of Congressman Ellen O. Tauscher.
• Congressman William L. "Bill" Owens (Democratic New York CD 23) was elected in a special election 3 November 2009. He will fill the vacancy caused by the resignation of Congressman John McHugh.
• Congressman R. Parker "Parker" Griffith (Democratic, Alabama CD 5) changed his affiliation to the Republican Party on 22 December 2009.
• Congressman Robert Wexler (Democratic, Florida CD 19) resigned 3 January 2010 to become President of the Center for Middle East Peace.
• Congressman John Patrick Murtha, Jr. (Democratic, Pennsylvania CD 12) passed away 8 February 2010 at the age of 77 due to complications from gall bladder surgery.
• Congressman Neil Abercrombie (Democratic, Hawaii CD 1) resigned 28 February 2010 at to devote his time to his Gubernatorial run.
• Congressman Eric J. J. Massa (Democratic, New York CD 29) resigned 8 March 2010 after a sexual harassment scandal and an announcement that he has Non-Hodgkin Lymphoma.
• Congressman Nathan Deal (Republican, Georgia, CD 9) resigned 21 March 2010 to devote his time to his campaign for Governor.
• Congressman Theodore Eliot "Ted" Deutch (Democratic, Florida CD 19) was elected in a special election on 13 April 2010. He will fill the vacancy caused by the resignation of Congressman Robert Wexler who became President of the Center for Middle East Peace.
• Congressman Mark S. Critz (Democratic Pennsylvania, CD 12) was elected in a special election on 18 May 2010. He fills the vacant seat of Congressman John Patrick Murtha, Jr. (Democratic) who passed away 8 February 2010.
• Congressman Mark Edward Souder (Republican, Indiana CD 3) announced his resignation on 18 May 2010 and officially resigned on 21 May.
• Congressman Charles Kong Djou (Republican, Hawaii CD 1) was elected in a special election on 22 May 2010 and seated on 25 May. He fill's the vacant seat of Congressman Neil Abercrombie who resigned to focus on his campaign for Governor.
• Congressman John Thomas "Tom" Graves, Jr. (Republican, Georgia CD 9) was elected in a special election on 8 June 2010 and seated on 14 June. He fill's the vacant seat of Congressman Nathan who resigned on 21 March to devote his time to his campaign for Governor.
• Congressman Marlin Stutzman (Republican, Indiana, CD 3) won the 2 November 2010 special election to fill the seat of former Congressman Mark Edward Souder (Republican).
• Thomas W. "Tom" Reed, II (Republican, New York, CD 29) won the 2 November 2010 special election to fill the seat of former Congressman Eric J. J. Massa (Democratic).
• Congressman Mark Steven Kirk (Republican, Illinois CD 10) ran for and was elected to the Class 3 U.S. Senate Seat on 2 November 2010. He resigned from Congress on 29 November 2010 to take his new seat in the Senate.