|Incumbent||Party||Office||Reason for not seeking re-election|
|Senator Richard C. Shelby||Republican||Senate Class 3||Open Seat. 8 February 2021: Senator Shelby, 86, will not run for re-election. "Today I announce that I will not seek a seventh term in the United State Senate in 2022."|
|Congressman Morris J. "Mo" Brooks, Jr.||Republican||House CD 5||Open Seat. 22 March 2021: Member of Congress Mo Brooks is a candidate for the Senate Class 3 in 2022.|
|Governor Doug Ducey||Republican||Governor||Open Chair. Term Limit. At Term Limit|
|Congressman Ann Kirkpatrick||Democratic||House CD 2||Open Seat. 12 March 2021: "I have decided not to seek re-election in 2022."|
|Governor Asa Hutchinson||Republican||Governor||Open Chair. Term Limit. At Term Limit|
Running for Attorney General in 2022.
|Governor John Charles Carney, Jr.||Democratic||Governor||Open Chair. Term Limit|
|Congressman Alcee L. Hastings||Democratic||House CD 20||Vacant Office. 6 April 2021: Member of Congress of Alcee L. Hastings, 84, passed away from pancreatic cancer.|
|Congressman Jody B. Hice||Republican||House CD 10||Open Seat. 22 March 2021: Candidate for Secretary of State in 2022.|
|Governor David Yutaka Ige||Democratic||Governor||Open Chair. Term Limit|
|Governor Eric Joseph Holcomb||Republican||Governor||Open Chair. Term Limit|
|Governor John Bel Edwards||Democratic||Governor||Open Chair. Term Limit. At Term Limit|
|Congressman Cedric L. Richmond||Democratic||House CD 2||Vacant Office. 7 January 2021: Member of Congress Cedric L. Richmond submitted his resignation effective 15 January 2021.|
|Governor Lawrence J. "Larry" Hogan, Jr.||Republican||Governor||Open Chair. Term Limit|
|Senator Roy Blunt||Republican||Senate Class 3||Open Seat. 8 March 2021: "I won't be a candidate for re-election to the U.S. Senate next year."|
|Governor Michael L. "Mike" Parson||Republican||Governor||Open Chair. Term Limit|
|Governor Greg Gianforte||Republican||Governor||Open Chair|
|Governor J. Peter "Pete" Ricketts||Republican||Governor||Open Chair. Term Limit. At Term Limit|
|Congressman Debra A. "Deb" Haaland||Democratic||House CD 1||Vacant Office. 17 December 2020: Nominated by President-elect Joe Biden Secretary of the Interior.|
15 March 2021: Confirmed by the U.S. Senate as Secretary of the Interior, 51-40
16 March 2021: Resigned.
|Congressman Lee Michael Zeldin||Republican||House CD 1||Open Seat. 8 April 2021: Announced his candidacy for Governor.|
|Congressman Thomas W. "Tom" Reed, II||Republican||House CD 23||Open Seat. 21 March 2021: Announced that he will not run for re-election due to alcohol dependence and allegations of sexually harassment.|
|Senator Richard Mauze Burr||Republican||Senate Class 3||Open Seat. circa 20 July 2016: Senator Richard Mauze Burr announces this will be his last run for re-election.|
|Governor Roy Asberry Cooper, III||Democratic||Governor||Open Chair. Term Limit|
|Senator Robert Jones "Rob" Portman||Republican||Senate Class 3||Open Seat. 25 January 2021: Not running for re-election.|
|Congressman Marcia L. Fudge||Democratic||House CD 11||Vacant Office. 8 December 2020: Member of Congress Marcia L. Fudge (Democratic) is nominated by apparent President-elect Joseph R. Biden, Jr. as Secretary of Housing and Urban Development.|
10 March 2021: Confirmed by the U.S. Senate, 66-34.
10 March 2021: Resigned.
|Governor Kate Brown||Democratic||Governor||Open Chair. Term Limit|
|Senator Patrick Joseph "Pat" Toomey||Republican||Senate Class 3||Open Seat. 6 October 2020: "I will not be running for reelection in 2022 and ... will not be running for governor ... I will serve out the remainder of my term."|
|Governor Thomas W. "Tom" Wolf||Democratic||Governor||Open Chair. Term Limit|
|Congressman Ron Wright||Republican||House CD 6||Vacant Office. 7 February 2021: Member of Congress Ron Wright, 67, has passed away from COVID-19 and lung cancer.|
|Congressman Kevin Patrick Brady||Republican||House CD 8||Open Seat. 14 April 2021: Announced he will not seek re-election-- "I am retiring as your Congressman. This term, my 13th, will be my last..."|
|Congressman Filemon B. Vela||Democratic||House CD 34||Open Seat. 22 March 2021: "I will not be seeking reelection to the House of Representatives in 2022...."|
|Governor Ralph S. Northam||Democratic||Governor||Open Chair. Term Limit. |
Nominations-- Democrats will nominate by Primary. Republicans will nominate by Convention at remote voting locations on 8 May.
|Governor James C. "Jim" Justice||Republican||Governor||Open Chair. Term Limit|
|Office||Reason for Open Chair or Seat|
Parties appear in parenthesis and italics when a candidate receives the endorsement of a given Party and/or official sources indicate a candidate's association with a particular Party but only where the Party in question does not appear on the actual ballot as such.
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