Governor's Chairs, Senate and House Seats...
Open (incumbent not running for re-election)
No incumbent running
Uncontested (one candidate running)
Multiple incumbents running
| Incumbent | Party | Office | Reason for not seeking re-election |
| Alabama | |||
| Senator Richard C. Shelby | Republican | Senate Class 3 | Open Seat. 8 February 2021: Senator Shelby, 86, will not run for re-election. "Today I announce that I will not seek a seventh term in the United State Senate in 2022." |
| Congressman Morris J. "Mo" Brooks, Jr. | Republican | House CD 5 | Open Seat. 22 March 2021: Member of Congress Mo Brooks is a candidate for the Senate Class 3 in 2022. |
| Arizona | |||
| Governor Doug Ducey | Republican | Governor | Open Chair. Term Limit. At Term Limit |
| Congressman Ann Kirkpatrick | Democratic | House CD 2 | Open Seat. 12 March 2021: "I have decided not to seek re-election in 2022." |
| Arkansas | |||
| Governor Asa Hutchinson | Republican | Governor | Open Chair. Term Limit. At Term Limit Running for Attorney General in 2022. |
| Delaware | |||
| Governor John Charles Carney, Jr. | Democratic | Governor | Open Chair. Term Limit |
| Florida | |||
| Congressman Alcee L. Hastings | Democratic | House CD 20 | Vacant Office. 6 April 2021: Member of Congress of Alcee L. Hastings, 84, passed away from pancreatic cancer. |
| Georgia | |||
| Congressman Jody B. Hice | Republican | House CD 10 | Open Seat. 22 March 2021: Candidate for Secretary of State in 2022. |
| Hawaii | |||
| Governor David Yutaka Ige | Democratic | Governor | Open Chair. Term Limit |
| Indiana | |||
| Governor Eric Joseph Holcomb | Republican | Governor | Open Chair. Term Limit |
| Louisiana | |||
| Governor John Bel Edwards | Democratic | Governor | Open Chair. Term Limit. At Term Limit |
| Congressman Cedric L. Richmond | Democratic | House CD 2 | Vacant Office. 7 January 2021: Member of Congress Cedric L. Richmond submitted his resignation effective 15 January 2021. |
| Maryland | |||
| Governor Lawrence J. "Larry" Hogan, Jr. | Republican | Governor | Open Chair. Term Limit |
| Missouri | |||
| Senator Roy Blunt | Republican | Senate Class 3 | Open Seat. 8 March 2021: "I won't be a candidate for re-election to the U.S. Senate next year." |
| Governor Michael L. "Mike" Parson | Republican | Governor | Open Chair. Term Limit |
| Montana | |||
| Governor Greg Gianforte | Republican | Governor | Open Chair |
| Nebraska | |||
| Governor J. Peter "Pete" Ricketts | Republican | Governor | Open Chair. Term Limit. At Term Limit |
| New Mexico | |||
| Congressman Debra A. "Deb" Haaland | Democratic | House CD 1 | Vacant Office. 17 December 2020: Nominated by President-elect Joe Biden Secretary of the Interior. 15 March 2021: Confirmed by the U.S. Senate as Secretary of the Interior, 51-40 16 March 2021: Resigned. |
| New York | |||
| Congressman Lee Michael Zeldin | Republican | House CD 1 | Open Seat. 8 April 2021: Announced his candidacy for Governor. |
| Congressman Thomas W. "Tom" Reed, II | Republican | House CD 23 | Open Seat. 21 March 2021: Announced that he will not run for re-election due to alcohol dependence and allegations of sexually harassment. |
| North Carolina | |||
| Senator Richard Mauze Burr | Republican | Senate Class 3 | Open Seat. circa 20 July 2016: Senator Richard Mauze Burr announces this will be his last run for re-election. |
| Governor Roy Asberry Cooper, III | Democratic | Governor | Open Chair. Term Limit |
| Ohio | |||
| Senator Robert Jones "Rob" Portman | Republican | Senate Class 3 | Open Seat. 25 January 2021: Not running for re-election. |
| Congressman Marcia L. Fudge | Democratic | House CD 11 | Vacant Office. 8 December 2020: Member of Congress Marcia L. Fudge (Democratic) is nominated by apparent President-elect Joseph R. Biden, Jr. as Secretary of Housing and Urban Development. 10 March 2021: Confirmed by the U.S. Senate, 66-34. 10 March 2021: Resigned. |
| Oregon | |||
| Governor Kate Brown | Democratic | Governor | Open Chair. Term Limit |
| Pennsylvania | |||
| Senator Patrick Joseph "Pat" Toomey | Republican | Senate Class 3 | Open Seat. 6 October 2020: "I will not be running for reelection in 2022 and ... will not be running for governor ... I will serve out the remainder of my term." |
| Governor Thomas W. "Tom" Wolf | Democratic | Governor | Open Chair. Term Limit |
| Texas | |||
| Congressman Ron Wright | Republican | House CD 6 | Vacant Office. 7 February 2021: Member of Congress Ron Wright, 67, has passed away from COVID-19 and lung cancer. |
| Congressman Kevin Patrick Brady | Republican | House CD 8 | Open Seat. 14 April 2021: Announced he will not seek re-election-- "I am retiring as your Congressman. This term, my 13th, will be my last..." |
| Congressman Filemon B. Vela | Democratic | House CD 34 | Open Seat. 22 March 2021: "I will not be seeking reelection to the House of Representatives in 2022...." |
| Virginia | |||
| Governor Ralph S. Northam | Democratic | Governor | Open Chair. Term Limit. Nominations-- Democrats will nominate by Primary. Republicans will nominate by Convention at remote voting locations on 8 May. |
| West Virginia | |||
| Governor James C. "Jim" Justice | Republican | Governor | Open Chair. Term Limit |
| Tally | |||||
| Office | Reason for Open Chair or Seat | ||||
| Voluntary | Term Limit | Vacant | Total | ||
| Senator | Republican | 5 | 0 | 0 | 5 |
| Congressman | Republican | 5 | 0 | 1 | 6 |
| Democratic | 2 | 0 | 4 | 6 | |
| Governor | Republican | 1 | 7 | 0 | 8 |
| Democratic | 0 | 7 | 0 | 7 | |
| Totals | 13 | 14 | 5 | 32 | |
Parties appear in parenthesis and italics when a candidate receives the endorsement of a given Party and/or official sources indicate a candidate's association with a particular Party but only where the Party in question does not appear on the actual ballot as such. |
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