This is a list of the current House seats and the incumbents occupying them. All 435 of these seats are up for election on 7 November 2006.

There have been 1 death, 6 resignations, and 0 changes of party affiliation in the 109^th House.

• 1 January 2005 - Congressman Robert T. "Bob" Matsui - Democrat - California CD 5 passed away at the age of 63.
• 8 March 2005 - Special Election - California CD 5. Doris Matsui (Democrat), the wife of the late Congressman Robert T. "Bob" Matsui, is elected to fill the vacant seat.
• 29 April 2005 - Congressman Rob Portman - Republican - Ohio CD 2. The U.S. Senate confirmed the nomination of Congressman Portman as U.S. Trade Representative. Congressman Portman issued a letter of resignation from his House Seat effective 29 April 2005.
• 2 August 2005 - Special Electon - Ohio CD 2. Jean Schmidt (Republican) is elected to fill the vacant seat.
• 2 August 2005 - Congressman Christopher Cox - Republican - California CD 48 resigned. President George W. Bush nominated Congressman Christopher Cox to the position of Chairman of the Securities and Exchange Commission on 2 June 2005.
• 28 November 2005 - Congressman Randy "Duke" Cunningham - Republican - California CD 50 resigned, effective at close of business 1 December, from the U.S. House after pleading guilty to Federal charges involving bribes, mail fraud, wire fraud, and tax evasion.
• 18 January 2006 - Congressman Robert "Bob" Menendez- Democrat- New Jersey CD 13 resigned. Governor Jon S. Corzine appointed Congressman Menendez to fill a vacancy in New Jersey's Class 1 U.S. Senate seat caused by Corzine himself having resigned the seat on 17 January 2006 upon taking the Oath of Office as Governor of New Jersey.
• 6 June 2006 - Special Election - California CD 50. Former Congressman Brian Phillip Bilbray (Republican) is elected to fill the vacant seat.
• 9 June 2006 - Congressman Thomas Dale "Tom" DeLay - Republican - Texas CD 22 resigned. House Majority Leader DeLay was indicted on one count of criminal conspiracy in a campaign finance scheme by a Texas grand jury on 28 September 2005. House rules required him to relinquish his leadership position. Mr. Delay was renominated in the 7 March 2006 Texas Primary but withdrew his nomination 4 April and announced his intention to resign on 11 May.
• 29 September 2006 - Congressman Mark Foley - Republican - Florida CD 16 resigned and withdrew his candidacy from the General Election. Mr. Foley had received his party's nomination in the 5 September primary.
• 3 November 2006 - Robert "Bob" Ney - Republican - Ohio CD 18 resigned. He pleaded guilty on 13 October 2006 to charges of conspiracy and making false statements in the Jack Abramoff scandal.
• 13 November 2006 - Albio Sires - Democrat - New Jersey CD 13 was elected 7 November 2006 in special election. Representative-elect Sires was added to the rolls of the House upon executing the oath of office.
• 13 November 2006 - Shelley Sekula Gibbs - Republican - Texas CD 22 was elected 7 November 2006 in special election. Representative-elect Gibbs was added to the rolls of the House upon executing the oath of office.